青云英语翻译

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翻译结果1翻译结果2 翻译结果3翻译结果4翻译结果5

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先进的乳腺癌经常转移到骨骼,导致溶骨性病变,但底层机制知之甚少。在这里,我们报告说,核因子-κB(NF -κB)起着至关重要的作用,通过刺激破骨细胞在乳腺癌溶骨性骨转移。使用在体内骨转移模型,我们发现,构NF -κB在乳腺癌细胞中的活性的骨吸收特点溶骨性骨转移的关键。我们的NF -κB的主要目标确定为编码基因的粒细胞巨噬细胞集落刺激因子(GM - CSF),并发现它介导刺激破骨细胞的发展的乳腺癌溶骨性骨转移。此外,我们观察到,GM - CSF的表达,从个人与乳腺癌骨转移的肿瘤组织中NF -κB激活相关。这些结果揭示了在溶骨性骨转移通过GM - CSF诱导的NF -κB的新的和具体的作用,这表明

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晚期的乳腺癌经常移转到骨,导致溶骨性病变,却不甚了解了底层的机制。在这里我们报告该核 factor–κB (NF-κB) 通过刺激在乳腺癌溶骨性骨转移中发挥了至关重要的作用破骨细胞形成。我们使用一种体内骨转移模型,发现本构 NF-κB 活动在乳腺癌细胞中的溶骨性骨转移特性的骨吸收的关键。我们确定为主要目标的 NF-κB 粒细胞集落刺激因子 (GM-CSF) 的 macrophage–colony 基因,发现它介于刺激破骨细胞发展的溶骨性骨转移的乳腺癌。此外,我们观察到与 NF-κB 激活个人乳腺癌骨转移性肿瘤组织中的表达 GM-CSF 的相关。这些结果发现新的和特定 NF-κB 的作用,通过

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先进乳癌经常繁殖,骨,结果osteolytic病变,不过基本机制是了解甚少。 在这里我们报告,核因素-κb(NF-κb)发挥了关键的作用osteolytic骨转移乳癌的刺激osteoclastogenesis。 在一个使用Vivo骨转移模式,我们发现,组织架NF-κb活动在乳腺癌细胞是至关重要的是骨吸回osteolytic骨转移的特点。

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